Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure
نویسندگان
چکیده
منابع مشابه
62 Analysis of T Cell Alloreactivity
The genetic and biochemical basis for the inclusion of T cell alloreactivity within the immunological repertoire of T helper (Tn) 1 lymphocytes remains a perplexing problem (1, 2). Recent evidence (3-9) suggests that the ability of Tn cells to bind to molecular complexes formed on antigen-presenting ceils between a nominal antigen and either self or nonself (allo) Ia molecules regulates their d...
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HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we addressed the impact of lymphopenia and chronic exposure to IFN-α on T cell homeostasis. In a ly...
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بسیاری از پدیده ها در جهان ما اساساً غیرخطی هستند، و توسط معادلات غیرخطی بیان شده اند. از آنجا که ظهور کامپیوترهای رقمی با عملکرد بالا، حل مسایل خطی را آسان تر می کند. با این حال، به طور کلی به دست آوردن جوابهای دقیق از مسایل غیرخطی دشوار است. روش عددی، به طور کلی محاسبه پیچیده مسایل غیرخطی را اداره می کند. با این حال، دادن نقاط به یک منحنی و به دست آوردن منحنی کامل که اغلب پرهزینه و ...
15 صفحه اولOn the nature of peptides involved in T cell alloreactivity
The strong reaction of T cells against foreign major histocompatibility complex (MHC) antigens, commonly termed "alloreactivity", is not only a nuisance for clinical organ transplantation; it also remains a puzzling question for immunologists. By making use of recent technical developments, alloreactive T cells nominally directed against a mutation in a single MHC class I molecule were found to...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2008
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/dxn023